4-(4'-methylbiphenyl-2-carboxamido)-N-methyl-N-(2-ethoxycarbonylphenyl)benzamide → 4-(4'-methylbiphenyl-2-carboxamido)-N-methyl-N-(2-carboxyphenyl)benzamide

Participants

Reaction Steps

A solution of 4-(4′-methylbiphenyl-2-carboxamido)-N-methyl-N-(2-ethoxycarbonylphenyl)benzamide (500 mg) in a mixture of ethanol (20 ml) and 1N sodium hydroxide (2 ml) was heated at reflux for 4 hours and ethanol was evaporated in vacuo. Water (5 ml) was added to the residue and the aqueous solution was adjusted to pH 2 with 1N hydrochloric acid. The precipitate was filtered to give 4-(4′-methylbiphenyl-2-carboxamido)-N-methyl-N-(2-carboxyphenyl)benzamide (435 mg) as a white powder.

Provenance & Evidence