反应详情

温度

-78 °C

Combine (1H-benzimidazol-2-yl)(1-benzylpiperidin-4-yl)amine (0.5 g, 1.6 mmol) and tetrahydrofuran (10 mL). Cool to −78° C. Add dropwise, a solution of potassium bis(trimethylsilyl)amide (3.6 mL, 0.5 M in toluene, 1.8 mmol). After 30 minutes, add 2-chloroethyl ethyl ether (0.2 g, 1.8 mmol). Warm to ambient temperature and heat to reflux. After 4 hours, add 2-chloroethyl ethyl ether (0.2 g, 1.8 mmol) and tetrabutylammonium bromide (0.1 g). After 12 hours, cool to ambient temperature and add water. Separate the organic layer and extract the aqueous layer with dichloromethane. Dry the combined organic layers over Na2SO4, filter, and evaporate in vacuo to give a residue. Chromatograph the residue on silica gel eluting with 2% triethylamine/10% methanol/ethyl acetate to give (1-(2-ethoxyethyl)-1H-benzimidazol-2-yl)(1-benzylpiperidin-4-yl)amine: Rf=0.55 (2% triethylamine/10% methanol/ethyl acetate).

1. additionAdd dropwise
2. temperatureWarm to ambient temperature
3. temperatureheat to reflux
4. waitAfter 4 hours
5. waitAfter 12 hours
6. temperaturecool to ambient temperature
7. customSeparate the organic layer
8. extractionextract the aqueous layer with dichloromethane
9. dry with materialDry the combined organic layers over Na2SO4
10. filtrationfilter
11. customevaporate in vacuo
12. customto give a residue