反应详情

Combine (1-methyl-1H-benzimidazol-2-yl)(1-ethoxycarbonylpiperidin-4-yl)amine (0.42 g, 1.4 mmol) and 48% hydrobromic acid (25 mL). Heat to reflux. After 3 hours, cool add water and a solution of potassium hydroxide (5 g) in water (50 mL). Extract twice with dichloromethane. Dry the organic layer over Na2SO4, filter, and evaporate in vacuo to give the title compound.

1. temperatureHeat to reflux
2. temperaturecool
3. extractionExtract twice with dichloromethane
4. dry with materialDry the organic layer over Na2SO4
5. filtrationfilter
6. customevaporate in vacuo