反应详情

Combine (+)-1-(3,4,5-trimethoxybenzoyl)-3-(3,4-dichlorophenyl)-3-(2-acetoxyethyl)pyrrolidine (670 mg, 1.35 mmol) and aqueous lithium hydroxide solution (4.2 mL, 1M) in methanol (15 mL). After 3.5 hours, concentrate in vacuo to give a residue. Dissolve the residue in dichloromethane and extract with 1M hydrochloric acid solution and saturated sodium bicarbonate solution. Dry the organic layer over MgSO4, filter, and concentrate in vacuo to obtain a residue. The residue was dried under high vacuum for 18 hours to give (S)-1-(3,4,5-trimethoxybenzoyl)-3-(3,4-dichlorophenyl)-3-(2-hydroxyethyl)pyrrolidine: Rf=0.11 (silica gel, ethyl acetate).

1. concentrationconcentrate in vacuo
2. customto give a residue
3. extractionextract with 1M hydrochloric acid solution and saturated sodium bicarbonate solution
4. dry with materialDry the organic layer over MgSO4
5. filtrationfilter
6. concentrationconcentrate in vacuo
7. customto obtain a residue
8. customThe residue was dried under high vacuum for 18 hours