HRID323278

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID607486

(3-Bromopropoxy)-tert-butyldimethylsilane

C9H21BrOSi

结构：COc1cc(CN2CCC(Cc3ccc(F)cc3)C2=O)cc(OC)c1OC

HCID18464944

未命名化合物

PRODUCTS

生成物

结构：COc1cc(CN2CCC(CCCO[Si](C)(C)C(C)(C)C)(Cc3ccc(F)cc3)C2=O)cc(OC)c1OC

HCID18464618

未命名化合物

PROCEDURE

实验过程

Prepare by the method of Example 17.3 using 1-(3,4,5-trimethoxybenzyl)-3-(4-fluorophenylmethyl)-2-oxopyrrolidine and 3-t-butyldimethylsilyloxypropyl bromide to give the title compound: Rf=0.52 (silica gel, 1/4 ethyl acetate/hexane).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-0c5bd37d973c4e529deeab1956f8afc1
来源数据集: uspto-grants-2001_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06211199B1
来源说明: uspto-grants-2001_04

反应 SMILES

[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:21]=[C:22]([O:26][CH3:27])[C:23]=1[O:24][CH3:25])[CH2:6][N:7]1[CH2:11][CH2:10][CH:9]([CH2:12][C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=2)[C:8]1=[O:20].[Si:28]([O:35][CH2:36][CH2:37][CH2:38]Br)([C:31]([CH3:34])([CH3:33])[CH3:32])([CH3:30])[CH3:29]>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:21]=[C:22]([O:26][CH3:27])[C:23]=1[O:24][CH3:25])[CH2:6][N:7]1[CH2:11][CH2:10][C:9]([CH2:12][C:13]2[CH:14]=[CH:15][C:16]([F:19])=[CH:17][CH:18]=2)([CH2:38][CH2:37][CH2:36][O:35][Si:28]([C:31]([CH3:32])([CH3:34])[CH3:33])([CH3:29])[CH3:30])[C:8]1=[O:20]