HuagongsheHuagongshe Chemistry Print Report · For research reference only
(3-Bromopropoxy)(tert-butyl)dimethylsilane → 1-(3,4,5-Trimethoxybenzyl)-3-(4-fluorophenylmethyl)-3-(3-t-butyldimethylsilyloxypropyl)-2-oxopyrrolidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (3-Bromopropoxy)(tert-butyl)dimethylsilane | HCID 607486 | — |
| Reactant | 1-(3,4,5-Trimethoxybenzyl)-3-(4-fluorophenylmethyl)-2-oxopyrrolidine | HCID 18464944 | — |
| Product | 1-(3,4,5-Trimethoxybenzyl)-3-(4-fluorophenylmethyl)-3-(3-t-butyldimethylsilyloxypropyl)-2-oxopyrrolidine | HCID 18464618 | — |
Reaction Steps
Prepare by the method of Example 17.3 using 1-(3,4,5-trimethoxybenzyl)-3-(4-fluorophenylmethyl)-2-oxopyrrolidine and 3-t-butyldimethylsilyloxypropyl bromide to give the title compound: Rf=0.52 (silica gel, 1/4 ethyl acetate/hexane).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06211199B1 |
| Source dataset | uspto-grants-2001_04 |
| ORD ID | ord-0c5bd37d973c4e529deeab1956f8afc1 |
| Source note | uspto-grants-2001_04 |