Methanesulfonic Acid → HCID 22009255, compound

HRID 323291Notes

Reaction equation

[CH3:1][O:2][C:3]1[CH:46]=[CH:45][CH:44]=[CH:43][C:4]=1[CH2:5][N:6]1[CH2:10][CH2:9][C:8]([CH2:19][CH2:20][N:21]2[CH2:26][CH2:25][CH:24]([NH:27][C:28]3[N:32]([CH2:33][CH2:34][O:35][CH2:36][CH3:37])[C:31]4[CH:38]=[CH:39][CH:40]=[CH:41][C:30]=4[N:29]=3)[CH2:23][CH2:22]2)([CH2:11][C:12]2[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=2)[C:7]1=[O:42].[CH3:47][S:48]([OH:51])(=[O:50])=[O:49]>>[CH3:47][S:48]([OH:51])(=[O:50])=[O:49].[CH3:1][O:2][C:3]1[CH:46]=[CH:45][CH:44]=[CH:43][C:4]=1[CH2:5][N:6]1[CH2:10][CH2:9][C:8]([CH2:19][CH2:20][N:21]2[CH2:26][CH2:25][CH:24]([NH:27][C:28]3[N:32]([CH2:33][CH2:34][O:35][CH2:36][CH3:37])[C:31]4[CH:38]=[CH:39][CH:40]=[CH:41][C:30]=4[N:29]=3)[CH2:23][CH2:22]2)([CH2:11][C:12]2[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=2)[C:7]1=[O:42]

Participants

Reactant 2

HCID 6395Methanesulfonic Acid

HCID 9895416HCID 9895416, compound

Product 1

HCID 22009255HCID 22009255, compound

Procedure

Prepare by the method of Example 16.8 using 1-(2-methoxybenzyl)-3-(2-(4-(1-(2-ethoxyethyl)-1H-benzimidazol-2-yl-amino)piperidin-1-yl)ethyl)-3-(4-fluorophenylmethyl)-2-oxopyrrolidine (1.2 g) and methanesulfonic acid (0.4 g, 4.9 mmol) to give the title compound.

Sources & evidence

ORD record: ord-e5ab4d603f0746f4a26e6dac00273a5a
Source dataset: uspto-grants-2001_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06211199B1

Reaction notes

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