Methanesulfonic Acid → HCID 22009284, compound

HRID 323295Notes

Reaction equation

[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:42]=[C:43]([O:47][CH3:48])[C:44]=1[O:45][CH3:46])[CH2:6][N:7]1[CH2:11][CH2:10][C:9]([CH2:18][CH2:19][N:20]2[CH2:25][CH2:24][CH:23]([NH:26][C:27]3[N:31]([CH2:32][CH2:33][O:34][CH2:35][CH3:36])[C:30]4[CH:37]=[CH:38][CH:39]=[CH:40][C:29]=4[N:28]=3)[CH2:22][CH2:21]2)([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:8]1=[O:41].[CH3:49][S:50]([OH:53])(=[O:52])=[O:51]>>[CH3:49][S:50]([OH:53])(=[O:52])=[O:51].[CH3:48][O:47][C:43]1[CH:42]=[C:5]([CH:4]=[C:3]([O:2][CH3:1])[C:44]=1[O:45][CH3:46])[CH2:6][N:7]1[CH2:11][CH2:10][C:9]([CH2:18][CH2:19][N:20]2[CH2:21][CH2:22][CH:23]([NH:26][C:27]3[N:31]([CH2:32][CH2:33][O:34][CH2:35][CH3:36])[C:30]4[CH:37]=[CH:38][CH:39]=[CH:40][C:29]=4[N:28]=3)[CH2:24][CH2:25]2)([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:8]1=[O:41]

Participants

Reactant 2

HCID 6395Methanesulfonic Acid

HCID 9809793HCID 9809793, compound

Product 1

HCID 22009284HCID 22009284, compound

Procedure

Prepare by the method of Example 16.8 using 1-(3,4,5-trimethoxybenzyl)-3-(2-(4-(1-(2-ethoxyethyl)-1H-benzimidazol-2-yl-amino)piperidin-1-yl)ethyl)-3-phenyl-2-oxopyrrolidine (1.5 g) and methanesulfonic acid (0.44 g 1.56 mmol) to give the title compound.

Sources & evidence

ORD record: ord-5d383bbb37d24b518b13d4be435504ab
Source dataset: uspto-grants-2001_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06211199B1

Reaction notes

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