Methanesulfonic Acid → 1-(3,4,5-Trimethoxybenzyl)-3-(3-(4-(1h-benzimidazol-2-yl-amino)piperidin-1-yl)propyl)-3-(4-fluorophenylmethyl)-2-oxopyrrolidine methanesulfonic acid salt

Participants

Reaction Steps

Combine 1-(3,4,5-trimethoxybenzyl)-3-(3-(4-(1H-benzimidazol-2-yl-amino)piperidin-1-yl)propyl)-3-(4-fluorophenylmethyl)-2-oxopyrrolidine (0.37 g, 0.56 mmol), methanesulfonic acid (0.17 g, 1.8 mmol), and ethyl acetate (10 mL). Heat to reflux. After 1 hour, cool to ambient temperature and add diethyl ether (75 mL). After 12 hour, collect the solid that forms and add diethyl ether (80 mL) and stir. After 12 hours, decant the solvent and collect the solid, rinse with diethyl ether and dry in vacuo to give the title compound.

Provenance & Evidence