反应详情

Combine 1-(3,4,5-trimethoxybenzyl)-3-(3-(4-(1H-benzimidazol-2-yl-amino)piperidin-1-yl)propyl)-3-(4-fluorophenylmethyl)-2-oxopyrrolidine (0.37 g, 0.56 mmol), methanesulfonic acid (0.17 g, 1.8 mmol), and ethyl acetate (10 mL). Heat to reflux. After 1 hour, cool to ambient temperature and add diethyl ether (75 mL). After 12 hour, collect the solid that forms and add diethyl ether (80 mL) and stir. After 12 hours, decant the solvent and collect the solid, rinse with diethyl ether and dry in vacuo to give the title compound.

1. temperatureHeat to reflux
2. waitAfter 12 hour
3. customcollect the solid that forms
4. additionadd diethyl ether (80 mL)
5. waitAfter 12 hours
6. customdecant the solvent
7. customcollect the solid
8. washrinse with diethyl ether
9. customdry in vacuo