Benzoyl chloride, 3,4,5-trimethoxy- → HCID 18464535, compound

HRID 323349Notes

Reaction equation

HRID 323349 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([C:7]2([CH2:12][CH2:13][OH:14])[CH2:11][CH2:10][NH:9][CH2:8]2)=[CH:3][CH:2]=1.[CH3:15][O:16][C:17]1[CH:18]=[C:19]([CH:23]=[C:24]([O:28][CH3:29])[C:25]=1[O:26][CH3:27])[C:20](Cl)=[O:21].C(=O)(O)[O-].[Na+]>>[CH3:29][O:28][C:24]1[CH:23]=[C:19]([CH:18]=[C:17]([O:16][CH3:15])[C:25]=1[O:26][CH3:27])[C:20]([N:9]1[CH2:10][CH2:11][C:7]([C:4]2[CH:5]=[CH:6][N:1]=[CH:2][CH:3]=2)([CH2:12][CH2:13][OH:14])[CH2:8]1)=[O:21]

Participants

4

Reactant 3

HCID 78282Benzoyl chloride, 3,4,5-trimethoxy-HCID 516892Sodium BicarbonateHCID 18464796HCID 18464796, compound

Product 1

HCID 18464535HCID 18464535, compound

Procedure

Prepare by the method of Example 5.2.2 using 3-(pyrid-4-yl)-3-(2-hydroxyethyl)-pyrrolidine, 3,4,5-trimethoxybenzoyl chloride, and sodium bicarbonate to give the title compound: Rf=0.42 (silica gel, 8% methanol/dichloromethane).

Sources & evidence

ORD record
ord-9aec898b11834d938281cc1d82431da4
Source dataset
uspto-grants-2001_04
Patent number
US06211199B1

Reaction notes

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