反应详情

Combine (1-(2-(isopropoxy)ethyl)-1H-benzimidazol-2-yl)(1-(t-butoxycarbonyl)piperidin-4-yl)amine (2.97 g, 7.38 mmol), aqueous hydriodic acid (5 mL, 57%), and ethanol (10 mL). Heat to reflux. After 1 hour, cool to ambient temperature and pour the reaction mixture into diethyl ether (350 mL) and stir to give a solid. After 1 hour, collect the solid by filtration, rinse with diethyl ether, and dry in vacuo to give the title compound.

1. temperatureHeat to reflux
2. customto give a solid
3. waitAfter 1 hour
4. customcollect the solid
5. filtrationby filtration
6. washrinse with diethyl ether
7. customdry in vacuo