Hydrochloric Acid → 1-(2-methoxy-5-(1H-tetrazol-1-yl)benzoyl)-3-(2-(4-(1-(2-(isopropyloxy)ethyl)-1H-benzimidazol-2-yl-amino)piperidin-1-yl)ethyl)-3-phenylpyrrolidine hydrochloric acid salt

HRID 323477Notes

Reaction equation

HRID 323477 reaction equation
[CH3:1][O:2][C:3]1[CH:45]=[CH:44][C:43]([N:46]2[CH:50]=[N:49][N:48]=[N:47]2)=[CH:42][C:4]=1[C:5]([N:7]1[CH2:11][CH2:10][C:9]([CH2:18][CH2:19][N:20]2[CH2:25][CH2:24][CH:23]([NH:26][C:27]3[N:31]([CH2:32][CH2:33][O:34][CH:35]([CH3:37])[CH3:36])[C:30]4[CH:38]=[CH:39][CH:40]=[CH:41][C:29]=4[N:28]=3)[CH2:22][CH2:21]2)([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH2:8]1)=[O:6].[Cl:51]CCl.Cl.O1CCOCC1>C(OCC)C>[ClH:51].[CH3:1][O:2][C:3]1[CH:45]=[CH:44][C:43]([N:46]2[CH:50]=[N:49][N:48]=[N:47]2)=[CH:42][C:4]=1[C:5]([N:7]1[CH2:11][CH2:10][C:9]([CH2:18][CH2:19][N:20]2[CH2:25][CH2:24][CH:23]([NH:26][C:27]3[N:31]([CH2:32][CH2:33][O:34][CH:35]([CH3:37])[CH3:36])[C:30]4[CH:38]=[CH:39][CH:40]=[CH:41][C:29]=4[N:28]=3)[CH2:22][CH2:21]2)([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH2:8]1)=[O:6]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 6344DichloromethaneHCID 312751,4-DioxaneHCID 98746781-(2-methoxy-5-(1H-tetrazol-1-yl)benzoyl)-3-(2-(4-(1-(2-(isopropyloxy)ethyl)-1H-benzimidazol-2-yl-amino)piperidin-1-yl)ethyl)-3-phenylpyrrolidine

Product 1

HCID 220091961-(2-methoxy-5-(1H-tetrazol-1-yl)benzoyl)-3-(2-(4-(1-(2-(isopropyloxy)ethyl)-1H-benzimidazol-2-yl-amino)piperidin-1-yl)ethyl)-3-phenylpyrrolidine hydrochloric acid salt

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Combine 1-(2-methoxy-5-(1H-tetrazol-1-yl)benzoyl)-3-(2-(4-(1-(2-(isopropyloxy)ethyl)-1H-benzimidazol-2-yl-amino)piperidin-1-yl)ethyl)-3-phenylpyrrolidine (0.42 g, 0.62 mmol) and dichloromethane (10 mL). Add a solution of hydrochloric acid in dioxane (0.4 mL, 4 M, 1.6 mmol). After 15 minutes, pour the reaction mixture into diethyl ether (300 mL) to give a solid. Collect the solid by filtration and dry in vacuo at 90° C. to give the title compound.

Workup

  1. customto give a solid
  2. customCollect the solid
  3. filtrationby filtration
  4. customdry in vacuo at 90° C.

Sources & evidence

ORD record
ord-5cb03b186b4c4b419ab48a4ff74b189c
Source dataset
uspto-grants-2001_04
Patent number
US06211199B1

Reaction notes

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