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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 323501Generated: October 25, 2026

Tecastemizole → 1-(3,4,5-trimethoxybenzyl)-3-(3-(4-(1-(4-fluorobenzyl)-1H-benzimidazol-2-yl-amino)piperidin-1-yl)propyl)-3-(4-fluorophenylmethyl)-2-oxopyrrolidine

https://huagongshe.com/reaction/323501

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTecastemizoleHCID 123618—
Reactant1-(3,4,5-Trimethoxybenzyl)-3-(4-fluorophenylmethyl)-3-(3-methanesulfonyloxypropyl)-2-oxopyrrolidineHCID 18464483—
Product1-(3,4,5-trimethoxybenzyl)-3-(3-(4-(1-(4-fluorobenzyl)-1H-benzimidazol-2-yl-amino)piperidin-1-yl)propyl)-3-(4-fluorophenylmethyl)-2-oxopyrrolidineHCID 9918400—

Reaction Steps

Prepare by the method of Example 23.4 using 1-(3,4,5-trimethoxybenzyl)-3-(4-fluorophenylmethyl)-3-(3-methanesulfonyloxypropyl)-2-oxopyrrolidine and (1-(4-fluorobenzyl)-1H-benzimidazol-2-yl)(piperidin-4-yl)amine to give the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06211199B1
Source datasetuspto-grants-2001_04
ORD IDord-9e44a0d99e324b64b42383ea1ab24496
Source noteuspto-grants-2001_04