Methanesulfonic Acid → 1-(3,4,5-trimethoxybenzyl)-3-(3-(4-(1-(4-fluorobenzyl)-1H-benzimidazol-2-yl-amino)piperidin-1-yl)propyl)-3-(4-fluorophenylmethyl)-2-oxopyrrolidine methanesulfonic acid salt
Reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:48]=[C:49]([O:53][CH3:54])[C:50]=1[O:51][CH3:52])[CH2:6][N:7]1[CH2:11][CH2:10][C:9]([CH2:20][CH2:21][CH2:22][N:23]2[CH2:28][CH2:27][CH:26]([NH:29][C:30]3[N:34]([CH2:35][C:36]4[CH:41]=[CH:40][C:39]([F:42])=[CH:38][CH:37]=4)[C:33]4[CH:43]=[CH:44][CH:45]=[CH:46][C:32]=4[N:31]=3)[CH2:25][CH2:24]2)([CH2:12][C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=2)[C:8]1=[O:47].[CH3:55][S:56]([OH:59])(=[O:58])=[O:57]>>[CH3:55][S:56]([OH:59])(=[O:58])=[O:57].[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:48]=[C:49]([O:53][CH3:54])[C:50]=1[O:51][CH3:52])[CH2:6][N:7]1[CH2:11][CH2:10][C:9]([CH2:20][CH2:21][CH2:22][N:23]2[CH2:24][CH2:25][CH:26]([NH:29][C:30]3[N:34]([CH2:35][C:36]4[CH:37]=[CH:38][C:39]([F:42])=[CH:40][CH:41]=4)[C:33]4[CH:43]=[CH:44][CH:45]=[CH:46][C:32]=4[N:31]=3)[CH2:27][CH2:28]2)([CH2:12][C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=2)[C:8]1=[O:47]Participants
3
Reactant 2
Product 1
Procedure
Prepare by the method of Example 109.2 using 1-(3,4,5-trimethoxybenzyl)-3-(3-(4-(1-(4-fluorobenzyl)-1H-benzimidazol-2-yl-amino)piperidin-1-yl)propyl)-3-(4-fluorophenylmethyl)-2-oxopyrrolidine and methanesulfonic acid to give the title compound: Rf=0.45 (silica gel, 2% triethylamine/10% methanol/ethyl acetate).
Sources & evidence
- ORD record
- ord-3f126cab4864475eac38b571683fd82b
- Source dataset
- uspto-grants-2001_04
- Patent number
- US06211199B1
Reaction notes
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