HRID323502

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6395

Methanesulfonic acid

CH4O3S

结构：COc1cc(CN2CCC(CCCN3CCC(Nc4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(Cc3ccc(F)cc3)C2=O)cc(OC)c1OC

HCID9918400

未命名化合物

PRODUCTS

生成物

结构：COc1cc(CN2CCC(CCCN3CCC(Nc4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(Cc3ccc(F)cc3)C2=O)cc(OC)c1OC.CS(=O)(=O)O

HCID22009316

未命名化合物

PROCEDURE

实验过程

Prepare by the method of Example 109.2 using 1-(3,4,5-trimethoxybenzyl)-3-(3-(4-(1-(4-fluorobenzyl)-1H-benzimidazol-2-yl-amino)piperidin-1-yl)propyl)-3-(4-fluorophenylmethyl)-2-oxopyrrolidine and methanesulfonic acid to give the title compound: Rf=0.45 (silica gel, 2% triethylamine/10% methanol/ethyl acetate).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-3f126cab4864475eac38b571683fd82b
来源数据集: uspto-grants-2001_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06211199B1
来源说明: uspto-grants-2001_04

反应 SMILES

[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:48]=[C:49]([O:53][CH3:54])[C:50]=1[O:51][CH3:52])[CH2:6][N:7]1[CH2:11][CH2:10][C:9]([CH2:20][CH2:21][CH2:22][N:23]2[CH2:28][CH2:27][CH:26]([NH:29][C:30]3[N:34]([CH2:35][C:36]4[CH:41]=[CH:40][C:39]([F:42])=[CH:38][CH:37]=4)[C:33]4[CH:43]=[CH:44][CH:45]=[CH:46][C:32]=4[N:31]=3)[CH2:25][CH2:24]2)([CH2:12][C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=2)[C:8]1=[O:47].[CH3:55][S:56]([OH:59])(=[O:58])=[O:57]>>[CH3:55][S:56]([OH:59])(=[O:58])=[O:57].[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:48]=[C:49]([O:53][CH3:54])[C:50]=1[O:51][CH3:52])[CH2:6][N:7]1[CH2:11][CH2:10][C:9]([CH2:20][CH2:21][CH2:22][N:23]2[CH2:24][CH2:25][CH:26]([NH:29][C:30]3[N:34]([CH2:35][C:36]4[CH:37]=[CH:38][C:39]([F:42])=[CH:40][CH:41]=4)[C:33]4[CH:43]=[CH:44][CH:45]=[CH:46][C:32]=4[N:31]=3)[CH2:27][CH2:28]2)([CH2:12][C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=2)[C:8]1=[O:47]