反应详情

Compound 8 (10 g, 0.04 mol) in 6 N HCl (50 mL) was heated at reflux for 10 h. This solution was neutralized with Na2CO3 (to pH 7 by litmus) and then extracted with EtOAc (3×150 mL). The combined EtOAc extracts were dried over magnesium sulfate, filtered and concentrated to give a solid residue, which, after recrystallization from EtOH, gave 6.3 g (97%) of compound 4 as a white solid (mp 140-141° C.).

1. temperatureat reflux for 10 h
2. extractionextracted with EtOAc (3×150 mL)
3. dry with materialThe combined EtOAc extracts were dried over magnesium sulfate
4. filtrationfiltered
5. concentrationconcentrated
6. customto give a solid residue, which
7. customafter recrystallization from EtOH