反应详情

温度

160 °C

7-Chloro-1-hydroxy-3-(4-methoxyphenyl)-3,4,5,10-tetrahydropyridazino[4,5-b]quinoline-4,10-dione (0.800 g, 2.16 mM) was stirred in methanesulfonic acid (16 mL) to give an amber solution. This solution was heated to 160° C. for 6 hours and cooled to room temperature. Addition of ethyl ether (250 mL) gave a tan precipitate which was stirred for 1 hour. The solid was collected and washed with methanol/ether to give the title compound (0.661 g, 77%) as a tan powder, mp 393-395° C.; MS(CI): 356 (M+H).

1. customto give an amber solution
2. temperaturecooled to room temperature
3. customgave a tan precipitate which
4. customThe solid was collected
5. washwashed with methanol/ether