反应详情

A mixture of the above piperidine (2.05 g, 7 mmol), ethyl bromoacetate (1.36 g, 8.1 mmol), potassium carbonate (1.7 g, 12.3 mmol) and acetone (50 ml) was heated at reflux temperature under stirring for 7 h. The mixture was filtered and the solvent evaporated in vacuo. The oily residue was purified on silica gel (20 g) using ethyl acetate as eluent to give 2.3 g (87%) 3-(10,11-dihydro-5H-dibenz[b,f]azepin-5-ylmethyl)-1-piperidylacetic acid ethyl ester as an oil.

1. temperaturewas heated
2. temperatureat reflux temperature
3. filtrationThe mixture was filtered
4. customthe solvent evaporated in vacuo
5. customThe oily residue was purified on silica gel (20 g)