Methanesulfonic Acid → HCID 88219091, compound

HRID 323793Notes

Reaction equation

[N:1]([CH2:4][CH:5]([C:7]1[CH:12]=[C:11]([S:13](=[O:16])(=[O:15])[NH2:14])[CH:10]=[CH:9][C:8]=1[O:17][CH3:18])[OH:6])=[N+]=[N-].[CH3:19][S:20](O)(=[O:22])=[O:21]>>[CH3:19][S:20]([O:6][CH:5]([CH2:4][NH2:1])[C:7]1[CH:12]=[C:11]([S:13](=[O:16])(=[O:15])[NH2:14])[CH:10]=[CH:9][C:8]=1[O:17][CH3:18])(=[O:22])=[O:21]

Participants

Reactant 2

HCID 6395Methanesulfonic Acid

HCID 22007168HCID 22007168, compound

Product 1

HCID 88219091HCID 88219091, compound

Procedure

Starting from (+)-α-azidomethyl-2-methoxy-5-sulphamoylbenzenemethanol, hydrogenated under the conditions described in step 6 of Example 2 and then treated with 1 equivalent of methanesulphonic acid, (+)-α-aminomethyl-2-methoxy-5-sulphamoylbenzenemethanol methanesulphonate was obtained.

Sources & evidence

ORD record: ord-dbf9d31343cc4b248217b156d575c7b6
Source dataset: uspto-grants-2001_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06214882B1

Reaction notes

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