反应详情

温度

170 °C

2,5-dichloropyridine (1.48 g; 10 mmol), 4-methylsulfonylphenol (1.89 g; 11 mmol) and Cs2CO3 (4.24 g; 13 mmol) was slurried in 75 mL of NMP. The slurry was heated to approx 170° C. over night. After cooling the Cs2CO3 was filtered off and the solvent was extracted between H2O and EtOAc. The organic phase was dried over Na2SO4 and evaporated. Heptane:EtOAc 2:1 was added to the residue and the crystalls was filtered off 1.42 g (50%).

1. filtrationwas filtered off
2. extractionthe solvent was extracted between H2O and EtOAc
3. dry with materialThe organic phase was dried over Na2SO4
4. customevaporated
5. additionHeptane:EtOAc 2:1 was added to the residue
6. filtrationthe crystalls was filtered off 1.42 g (50%)