反应详情

温度

100 °C

35.9 g (0.13 mol) of 7-benzylguanine hydrochloride from stage a) were dissolved in a mixture of 90 ml of water and 807 ml of glacial acetic acid and heated to 100° C. After cooling to 50° C., a solution of 35.88 g (0.52 mol) of sodium nitrite in 90 ml of water was added in one portion. After 16 hours at room temperature, the resulting precipitate was filtered off with suction, washed with water on the suction filter and dried.

1. temperatureAfter cooling to 50° C.
2. filtrationthe resulting precipitate was filtered off with suction
3. washwashed with water on the suction
4. filtrationfilter
5. customdried