HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 323859Generated: October 27, 2026
Sodium Nitrite → 7-Benzyl-1H-purine-2,6(3H,7H)-dione
https://huagongshe.com/reaction/323859
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Nitrite | HCID 23668193 | — |
| Reactant | 2-Amino-7-benzyl-1,7-dihydro-6H-purin-6-one hydrochloride | HCID 135682051 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Solvent | Water | HCID 962 | — |
| Product | 7-Benzyl-1H-purine-2,6(3H,7H)-dione | HCID 12500507 | — |
Reaction Steps
35.9 g (0.13 mol) of 7-benzylguanine hydrochloride from stage a) were dissolved in a mixture of 90 ml of water and 807 ml of glacial acetic acid and heated to 100° C. After cooling to 50° C., a solution of 35.88 g (0.52 mol) of sodium nitrite in 90 ml of water was added in one portion. After 16 hours at room temperature, the resulting precipitate was filtered off with suction, washed with water on the suction filter and dried.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06214992B1 |
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| Source dataset | uspto-grants-2001_04 |
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| ORD ID | ord-551dba0e031b4f2f9134e28d7e3c7d4b |
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| Source note | uspto-grants-2001_04 |
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