Potassium Carbonate → HCID 22007300, compound

HRID 323871Notes

Reaction equation

[CH2:1]([N:8]1[C:16]2[C:15](=[O:17])[NH:14][C:13](=[O:18])[N:12]([CH3:19])[C:11]=2[N:10]=[CH:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+].[CH3:26][O:27][CH2:28][CH2:29][O:30][CH2:31]Cl>C(#N)C>[CH2:1]([N:8]1[C:16]2[C:15](=[O:17])[N:14]([CH2:26][O:27][CH2:28][CH2:29][O:30][CH3:31])[C:13](=[O:18])[N:12]([CH3:19])[C:11]=2[N:10]=[CH:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

Conditions

Temperature: 50 °C

Procedure

The mixture of 25.6 g (0.1 mol) of 7-benzyl-3-methylxanthine (prepared according to Example 1a), 15.2 g (0.11 mol) of potassium carbonate and 16.2 g (0.13 mol) of 2-methoxyethoxymethyl chloride in 500 ml of acetonitrile was heated at 50° C. with stirring for 5 hours, then worked up analogously to Example 1b) and the oily product obtained was purified by means of filtration on a silica gel column in the eluent chloroform/methanol (10/1).

Workup

customobtained
filtrationwas purified by means of filtration on a silica gel column in the eluent chloroform/methanol (10/1)

Sources & evidence

ORD record: ord-ed40a02ba28544cd81ae0c041a868a89
Source dataset: uspto-grants-2001_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06214992B1

Reaction notes

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