反应详情

温度

50 °C

The mixture of 25.6 g (0.1 mol) of 7-benzyl-3-methylxanthine (prepared according to Example 1a), 15.2 g (0.11 mol) of potassium carbonate and 16.2 g (0.13 mol) of 2-methoxyethoxymethyl chloride in 500 ml of acetonitrile was heated at 50° C. with stirring for 5 hours, then worked up analogously to Example 1b) and the oily product obtained was purified by means of filtration on a silica gel column in the eluent chloroform/methanol (10/1).

1. customobtained
2. filtrationwas purified by means of filtration on a silica gel column in the eluent chloroform/methanol (10/1)