[2-(2-Thienyl)ethylamino](2-chlorophenyl)acetonitrile → [2-(2-Thienyl)ethylamino](2-chlorophenyl)acetonitrile hydrochloride

HRID 323883Notes

Reaction equation

HRID 323883 reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][CH2:7][NH:8][CH:9]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[Cl:18])[C:10]#[N:11]>C(O)C.Cl>[ClH:18].[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][CH2:7][NH:8][CH:9]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[Cl:18])[C:10]#[N:11]

Participants

4

Reactant 1

HCID 10858772[2-(2-Thienyl)ethylamino](2-chlorophenyl)acetonitrile

Product 1

HCID 21953220[2-(2-Thienyl)ethylamino](2-chlorophenyl)acetonitrile hydrochloride

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 702EthanolSolvent

Procedure

276.7 g (1 mol) of [2-(2-thienyl)ethylamino](2-chlorophenyl)acetonitrile, prepared according to example 1 or 2, is dissolved in 600 ml of ethanol, to the solution 600 ml of 10% aqueous hydrochloric acid solution is added. Within a few minutes white crystals precipitate, they are collected, washed with 60 ml of 1:1 mixture of 10% hydrochloric acid and ethanol, then with acetone, and they are dried. Weight: 305 g (97.4%), mp.: 153-154° C. The product was identified by elementary analysis, IR spectrum and 1H-NMR investigation.

Workup

  1. additionis added
  2. customWithin a few minutes white crystals precipitate, they are collected
  3. washwashed with 60 ml of 1:1 mixture of 10% hydrochloric acid and ethanol
  4. dry with materialwith acetone, and they are dried

Sources & evidence

ORD record
ord-6322313e5e1c4723add3d7c221aa09c4
Source dataset
uspto-grants-2001_04
Patent number
US06215005B1

Reaction notes

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