2-(chloromethyl)-N,N-dimethylaniline hydrochloride → 1-N-acetyl-2-(2-dimethylaminobenzylthio)-5-ethyl-5-methyl-2-imidazolin-4-one
Reaction equation
Cl.[CH3:2][N:3]([CH3:12])[C:4]1[CH:11]=[CH:10][CH:9]=[CH:8][C:5]=1[CH2:6]Cl.[C:13]([N:16]1[C:22]([CH2:24][CH3:25])([CH3:23])[C:20](=[O:21])[NH:19][C:17]1=[S:18])(=[O:15])[CH3:14]>>[C:13]([N:16]1[C:22]([CH2:24][CH3:25])([CH3:23])[C:20](=[O:21])[N:19]=[C:17]1[S:18][CH2:6][C:5]1[CH:8]=[CH:9][CH:10]=[CH:11][C:4]=1[N:3]([CH3:12])[CH3:2])(=[O:15])[CH3:14]Participants
3
Procedure
In the present Example, 2.27 g of 2-dimethylaminobenzylchloride hydrochloride and 2.0 g of 1-N-acetyl-5-ethyl-5-methyl-2-thiohydantoin were reacted following the procedure of Example 33. The desired compound was obtained in the form of needle-like crystal. The yield of this compound was 1.37 g with a yield ratio of 41.1%, and the melting point was 83°-85° C.
Sources & evidence
- ORD record
- ord-e6678ac22aa94fabbc9a581571db8c5e
- Source dataset
- uspto-grants-1998_03
- Patent number
- US05733922
Reaction notes
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