2-(chloromethyl)-N,N-dimethylaniline hydrochloride → 1-N-acetyl-2-(2-dimethylaminobenzylthio)-5-ethyl-5-methyl-2-imidazolin-4-one

Participants

Reaction Steps

In the present Example, 2.27 g of 2-dimethylaminobenzylchloride hydrochloride and 2.0 g of 1-N-acetyl-5-ethyl-5-methyl-2-thiohydantoin were reacted following the procedure of Example 33. The desired compound was obtained in the form of needle-like crystal. The yield of this compound was 1.37 g with a yield ratio of 41.1%, and the melting point was 83°-85° C.

Provenance & Evidence