Hydrochloric Acid → 4-(5-(4-Fluoro-phenyl)-pyridine-2-yl)-piperazine Hydrochloride

HRID 32391Notes

Reaction equation

HRID 32391 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[CH:10][C:11]([N:14]3[CH2:19][CH2:18][N:17](C=O)[CH2:16][CH2:15]3)=[N:12][CH:13]=2)=[CH:4][CH:3]=1.[ClH:22]>CO>[ClH:22].[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:9]=[CH:10][C:11]([N:14]3[CH2:15][CH2:16][NH:17][CH2:18][CH2:19]3)=[N:12][CH:13]=2)=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 231334904-(5-(4-Fluoro-phenyl)-pyridine-2-yl)-piperazine-1-carbaldehyde

Product 1

HCID 231335334-(5-(4-Fluoro-phenyl)-pyridine-2-yl)-piperazine HydrochlorideYield 100%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

4-(5-(4-Fluoro-phenyl)-pyridine-2-yl)-piperazine-1-carbaldehyde (98 mg, 0.34 mmol) was dissolved in MeOH (5 ml) and conc. HCl (12M, 5 ml) was added. The mixture was stirred at room temperature over night. The solvents were removed in vacuo and the remaining water was removed by azeotropic evaporation using EtOH/Toulene affording 102 mg (100%) of the title compound as a yellow powder.

Workup

  1. customThe solvents were removed in vacuo
  2. customthe remaining water was removed by azeotropic evaporation

Sources & evidence

ORD record
ord-455c44ff335c439684d046487c617b8f
Source dataset
uspto-grants-2008_09
Patent number
US07427631B2

Reaction notes

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