5-Chloro-2-(piperidin-4-yloxy)pyridine hydrochloride → 5-[({4-[(5-Chloropyridin-2-yl)oxy]piperidin-1-yl}sulfonyl)methyl]-5-{2-[(phenylmethyl)oxy]ethyl}imidazolidine-2,4-dione

HRID 32395Notes

Reaction equation

HRID 32395 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:8][CH:9]2[CH2:14][CH2:13][N:12]([S:15](CC3(CN4C(=O)C(C)(C)N(C)C4=O)NC(=O)NC3=O)(=[O:17])=[O:16])[CH2:11][CH2:10]2)=[N:6][CH:7]=1.Cl.ClC1C=CC(OC2CCNCC2)=NC=1.[O:52]=[C:53]1[NH:57][C:56]([CH2:68]S(Cl)(=O)=O)([CH2:58][CH2:59][O:60][CH2:61][C:62]2[CH:67]=[CH:66][CH:65]=[CH:64][CH:63]=2)[C:55](=[O:73])[NH:54]1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:8][CH:9]2[CH2:14][CH2:13][N:12]([S:15]([CH2:68][C:56]3([CH2:58][CH2:59][O:60][CH2:61][C:62]4[CH:67]=[CH:66][CH:65]=[CH:64][CH:63]=4)[NH:57][C:53](=[O:52])[NH:54][C:55]3=[O:73])(=[O:17])=[O:16])[CH2:11][CH2:10]2)=[N:6][CH:7]=1

Participants

4

Reactant 3

HCID 231334375-Chloro-2-(piperidin-4-yloxy)pyridine hydrochlorideHCID 231334915-[({4-[(5-Chloropyridin-2-yl)oxy]piperidin-1-yl}sulfonyl)methyl]-5-[(3,4,4-trimethyl-2,5-dioxoimidazolidin-1-yl)methyl]imidazolidine-2,4-dioneHCID 23133535(2,5-Dioxo-4-{2-[(phenylmethyl)oxy]ethyl}imidazolidin-4-yl)methanesulfonyl chloride

Product 1

HCID 231335605-[({4-[(5-Chloropyridin-2-yl)oxy]piperidin-1-yl}sulfonyl)methyl]-5-{2-[(phenylmethyl)oxy]ethyl}imidazolidine-2,4-dione

Procedure

The title compound was prepared as described in the synthesis of 5-[({4-[(5-chloropyridin-2-yl)oxy]piperidin-1-yl}sulfonyl)methyl]-5-[(3,4,4-trimethyl-2,5-dioxoimidazolidin-1-yl)methyl]imidazolidine-2,4-dione starting from 5-Chloro-2-(piperidine-4-yloxy)-pyridine hydrochloride and (2,5-dioxo-4-{2-[(phenylmethyl)oxy]ethyl}imidazolidin-4-yl)methanesulfonyl chloride.

Sources & evidence

ORD record
ord-19cf9f219fcc4f72a7ef87e51f84041f
Source dataset
uspto-grants-2008_09
Patent number
US07427631B2

Reaction notes

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