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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 32395Generated: October 26, 2026

5-Chloro-2-(piperidin-4-yloxy)pyridine hydrochloride → 5-[({4-[(5-Chloropyridin-2-yl)oxy]piperidin-1-yl}sulfonyl)methyl]-5-{2-[(phenylmethyl)oxy]ethyl}imidazolidine-2,4-dione

https://huagongshe.com/reaction/32395

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-Chloro-2-(piperidin-4-yloxy)pyridine hydrochlorideHCID 23133437—
Reactant5-[({4-[(5-Chloropyridin-2-yl)oxy]piperidin-1-yl}sulfonyl)methyl]-5-[(3,4,4-trimethyl-2,5-dioxoimidazolidin-1-yl)methyl]imidazolidine-2,4-dioneHCID 23133491—
Reactant(2,5-Dioxo-4-{2-[(phenylmethyl)oxy]ethyl}imidazolidin-4-yl)methanesulfonyl chlorideHCID 23133535—
Product5-[({4-[(5-Chloropyridin-2-yl)oxy]piperidin-1-yl}sulfonyl)methyl]-5-{2-[(phenylmethyl)oxy]ethyl}imidazolidine-2,4-dioneHCID 23133560—

Reaction Steps

The title compound was prepared as described in the synthesis of 5-[({4-[(5-chloropyridin-2-yl)oxy]piperidin-1-yl}sulfonyl)methyl]-5-[(3,4,4-trimethyl-2,5-dioxoimidazolidin-1-yl)methyl]imidazolidine-2,4-dione starting from 5-Chloro-2-(piperidine-4-yloxy)-pyridine hydrochloride and (2,5-dioxo-4-{2-[(phenylmethyl)oxy]ethyl}imidazolidin-4-yl)methanesulfonyl chloride.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07427631B2
Source datasetuspto-grants-2008_09
ORD IDord-19cf9f219fcc4f72a7ef87e51f84041f
Source noteuspto-grants-2008_09