HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydroxylamine → 4-[(R)-2-Amino-2-(butyl)ethoxymethyl]piperidine-1-carboxylic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydroxylamine | HCID 787 | — |
| Reactant | Tert-butyl 4-(methylsulfonyloxymethyl)piperidine-1-carboxylate | HCID 2765838 | — |
| Reactant | (R)-2-Aminohexan-1-ol | HCID 6994402 | — |
| Product | 4-[(R)-2-Amino-2-(butyl)ethoxymethyl]piperidine-1-carboxylic acid tert-butyl ester | HCID 69309660 | — |
Reaction Steps
Using amino alcohol alkylation method A, but adding 1.1 equivalents of 4-methanesulfonyloxymethyl-piperidine-1-carboxylic acid tert-butyl ester instead of 1 equivalent, (R)-norleucinol (400 mg, 3.4 mmol) afforded, after purification (SiO2: 7:3:1 hexane:EtOAc:isopropyl amine), 195 mg (18%) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07427632B2 |
| Source dataset | uspto-grants-2008_09 |
| ORD ID | ord-24de82dae18941629b383ae8ee4ce543 |
| Source note | uspto-grants-2008_09 |