HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(4'-Chlorobenzoyl)benzoic acid → 1-[2-{4-(4-chlorophenyl)-1(2H)-phthalazinon-2-yl}-4-pyridyl]-3-hydroxymethyl-6,7-diethoxynaphthalene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(4'-Chlorobenzoyl)benzoic acid | HCID 66564 | — |
| Reactant | 1-(2-Hydrazino-4-pyridyl)-3-hydroxymethyl-6,7-diethoxynaphthalene | HCID 22007332 | — |
| Solvent | Ethylene Glycol | HCID 174 | — |
| Product | 1-[2-{4-(4-chlorophenyl)-1(2H)-phthalazinon-2-yl}-4-pyridyl]-3-hydroxymethyl-6,7-diethoxynaphthalene | HCID 22007338 | 85.3% |
Reaction Steps
1-(2-Hydrazino-4-pyridyl)-3-hydroxymethyl-6,7-diethoxynaphthalene (177 mg), 1-carboxy-2-(4-chlorophenylcarbonyl)benzene (137 mg) and ethylene glycol (1 ml) are treated in the same manner as in Example 104-(3) to give 1-[2-{4-(4-chlorophenyl)-1(2H)-phthalazinon-2-yl}-4-pyridyl]-3-hydroxymethyl-6,7-diethoxynaphthalene (247 mg), which is listed in Table 14.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06214996B1 |
| Source dataset | uspto-grants-2001_04 |
| ORD ID | ord-4a2ea42d454c4699b72d33f0bb05dd31 |
| Source note | uspto-grants-2001_04 |