HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Chloro-1H-indole-6-carboxylic acid → 4-{2-[(3-Chloro-1H-indole-6-carbonyl)amino]-2-(2-pyridinyl)-ethoxymethyl}piperidine-1-carboxylic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Chloro-1H-indole-6-carboxylic acid | HCID 15543042 | — |
| Reactant | 4-[2-Amino-2-(2-pyridinyl)-ethoxymethyl]piperidine-1-carboxylic acid tert-butyl ester | HCID 69313232 | — |
| Product | 4-{2-[(3-Chloro-1H-indole-6-carbonyl)amino]-2-(2-pyridinyl)-ethoxymethyl}piperidine-1-carboxylic acid tert-butyl ester | HCID 69309680 | — |
Reaction Steps
Using coupling method A, 4-[2-amino-2-(2-pyridinyl)-ethoxymethyl]piperidine-1-carboxylic acid tert-butyl ester (730 mg, 2.2 mmol) and 3-chloroindole-6-carboxylic acid (468 mg, 2.4 mmol) afforded, after purification (SiO2: 10 DCM:2 EtOAc:2 Hexane:0 to 1.5 isopropyl amine), 835 mg (64%) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07427632B2 |
| Source dataset | uspto-grants-2008_09 |
| ORD ID | ord-346106756f7f41f3bc0a8290500aee09 |
| Source note | uspto-grants-2008_09 |