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HRID32419

反应详情

EQUATION

反应方程式

HRID 32419 的结构方程式

REACTANTS

反应物

2
结构：C=O
HCID712

Formaldehyde

CH2O

结构：Cl.O=C(N[C@@H](COCC1CCNCC1)c1ccccc1)c1ccc2c(Cl)c[nH]c2c1
HCID69307898

未命名化合物

PRODUCTS

生成物

1
结构：CN1CCC(COC[C@H](NC(=O)c2ccc3c(Cl)c[nH]c3c2)c2ccccc2)CC1
HCID69310601

未命名化合物

PROCEDURE

实验过程

Using alkylation method B, 3-chloro-N-[(R)-1-phenyl-2-(piperidin-4-ylmethoxy)ethyl]-1H-indole-6-carboxamide hydrochloride (200 mg, 0.44 mmol) and paraformaldehyde (134 mg, 4.4 mmol) afforded, after purification (SiO2: 2.5% isopropylamine in 10:2:2:DCM:EtOAc:hexane), 80 mg (42%) of the title compound.

WORKUP

后处理

  1. customafforded
  2. customafter purification (SiO2: 2.5% isopropylamine in 10:2:2:DCM:EtOAc:hexane), 80 mg (42%) of the title compound