HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formaldehyde → 3-Chloro-N-[(R)-1-phenyl-2-(1-methylpiperidin-4-yl-methoxy)ethyl]-1H-indole-6-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | HCID 69307898 | HCID 69307898 | — |
| Product | 3-Chloro-N-[(R)-1-phenyl-2-(1-methylpiperidin-4-yl-methoxy)ethyl]-1H-indole-6-carboxamide | HCID 69310601 | — |
Reaction Steps
Using alkylation method B, 3-chloro-N-[(R)-1-phenyl-2-(piperidin-4-ylmethoxy)ethyl]-1H-indole-6-carboxamide hydrochloride (200 mg, 0.44 mmol) and paraformaldehyde (134 mg, 4.4 mmol) afforded, after purification (SiO2: 2.5% isopropylamine in 10:2:2:DCM:EtOAc:hexane), 80 mg (42%) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07427632B2 |
| Source dataset | uspto-grants-2008_09 |
| ORD ID | ord-0b42e336fc9d428ea407c9443f8ab370 |
| Source note | uspto-grants-2008_09 |