Hydrogen Bromide → HCID 70247924, compound

HRID 324280Notes

Reaction equation

HRID 324280 reaction equation
Cl.C[O:3][C:4]1[C:18]([C:19]([OH:21])=[O:20])=[CH:17][C:7]2[N:8]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)[CH:9]=[N:10][C:6]=2[CH:5]=1.[BrH:22]>C(O)(=O)C>[BrH:22].[OH:3][C:4]1[C:18]([C:19]([OH:21])=[O:20])=[CH:17][C:7]2[N:8]([C:11]3[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=3)[CH:9]=[N:10][C:6]=2[CH:5]=1

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 70247567HCID 70247567, compound

Product 1

HCID 70247924HCID 70247924, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A solution of 5-methoxy-1-phenylbenzimidazole-6-carboxylic acid hydrochloride (0.60 g, 2.24 mmol) in a 33% solution of HBr in glacial acetic acid (50 mL) was refluxed for 30 hours. After cooling to room temperature, the resulting precipitate of the hydrobromide salt of Example 52 was filtered off (0.51 g, 68%): mp 288-290° C. (dec.).

Workup

  1. filtrationthe resulting precipitate of the hydrobromide salt of Example 52 was filtered off (0.51 g, 68%)

Sources & evidence

ORD record
ord-f35c83640c2d4b6bbc84ae638a4d04f0
Source dataset
uspto-grants-2001_04
Patent number
US06218388B1

Reaction notes

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