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HRID32430

反应详情

EQUATION

反应方程式

HRID 32430 的结构方程式

REACTANTS

反应物

2
结构：CC(C)=O
HCID180

Acetone

C3H6O

结构：O=C(NC(COCC1CCNCC1)c1ccccc1Cl)c1cc2cc(Cl)ccc2[nH]1
HCID69309648

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)N1CCC(COCC(NC(=O)c2cc3cc(Cl)ccc3[nH]2)c2ccccc2Cl)CC1
HCID69313025

未命名化合物

PROCEDURE

实验过程

Using alkylation method A, 5-chloro-N-[1-(2-chloro-phenyl)-2-(piperidin-4-ylmethoxy)ethyl]-1H-indole-2-carboxamide (320 mg, 0.72 mmol) and acetone (2.0 mL, 27 mmol) afforded, after purification (SiO2: 0 to 2.5% isopropylamine in 1:1 hexane:EtOAc) and recrystallization (acetonitrile), 185 mg (53%) of the title compound.

WORKUP

后处理

  1. customafforded
  2. customafter purification (SiO2: 0 to 2.5% isopropylamine in 1:1 hexane:EtOAc) and recrystallization (acetonitrile), 185 mg (53%) of the title compound