HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetone → 5-Chloro-N-[1-(2-chlorophenyl)-2-(1-isopropylpiperidin-4-yl-methoxy)ethyl]-1H-indole-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetone | HCID 180 | — |
| Reactant | 5-chloro-N-[1-(2-chloro-phenyl)-2-(piperidin-4-ylmethoxy)ethyl]-1H-indole-2-carboxamide | HCID 69309648 | — |
| Product | 5-Chloro-N-[1-(2-chlorophenyl)-2-(1-isopropylpiperidin-4-yl-methoxy)ethyl]-1H-indole-2-carboxamide | HCID 69313025 | — |
Reaction Steps
Using alkylation method A, 5-chloro-N-[1-(2-chloro-phenyl)-2-(piperidin-4-ylmethoxy)ethyl]-1H-indole-2-carboxamide (320 mg, 0.72 mmol) and acetone (2.0 mL, 27 mmol) afforded, after purification (SiO2: 0 to 2.5% isopropylamine in 1:1 hexane:EtOAc) and recrystallization (acetonitrile), 185 mg (53%) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07427632B2 |
| Source dataset | uspto-grants-2008_09 |
| ORD ID | ord-856810d339f04c569bb43603a677e55d |
| Source note | uspto-grants-2008_09 |