HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formaldehyde → HCID 69310611, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | HCID 69310707 | HCID 69310707 | — |
| Product | HCID 69310611 | HCID 69310611 | — |
Reaction Steps
Using alkylation method B, 3-chloro-N-[1-(2-fluoro-phenyl)-2-(piperidin-4-ylmethoxy)ethyl]-1H-indole-6-carboxamide (250 mg, 0.58 mmol) and paraformaldehyde (174 mg, 5.8 mmol) afforded, after purification (SiO2: 10:2:2:1 DCM:EtOAc:hexane:isopropylamine), 160 mg (63%) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07427632B2 |
| Source dataset | uspto-grants-2008_09 |
| ORD ID | ord-7a33ed80c89848e287faa47bc9ba1c20 |
| Source note | uspto-grants-2008_09 |