Hydrochloric Acid → HCID 22004417, compound

HRID 324344Notes

Reaction equation

HRID 324344 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:28]=[CH:29][C:30]=1[O:31][CH3:32])[CH2:5][NH:6][C:7]1[C:16]2[C:11](=[CH:12][CH:13]=[C:14]([C:17]#[N:18])[CH:15]=2)[C:10]([N:19]2[CH2:24][CH2:23][N:22]([CH2:25][CH2:26][OH:27])[CH2:21][CH2:20]2)=[N:9][N:8]=1.[ClH:33]>CC(C)=O>[ClH:1].[ClH:33].[Cl:1][C:2]1[CH:3]=[C:4]([CH:28]=[CH:29][C:30]=1[O:31][CH3:32])[CH2:5][NH:6][C:7]1[C:16]2[C:11](=[CH:12][CH:13]=[C:14]([C:17]#[N:18])[CH:15]=2)[C:10]([N:19]2[CH2:24][CH2:23][N:22]([CH2:25][CH2:26][OH:27])[CH2:21][CH2:20]2)=[N:9][N:8]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 22004369HCID 22004369, compound

Product 1

HCID 22004417HCID 22004417, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

4-(3-Chloro-4-methoxybenzyl)amino-6-cyano-1-[4-(2-hydroxyethyl)piperazin-1-yl]phthalazine (12.0 g, 26.5 mmol) prepared in a similar manner to that of Example 3 was suspended in 600 ml of acetone, followed by the addition of 60 ml of 1N hydrochloric acid. The obtained mixture was stirred at room temperature for 30 minutes to precipitate crystals, which were recovered by filtration and dried at 90° C. for 6 hours to give 13.06 g of the title compound as a pale-yellow powder.

Workup

  1. customto precipitate crystals, which
  2. filtrationwere recovered by filtration
  3. customdried at 90° C. for 6 hours

Sources & evidence

ORD record
ord-025e84a84fe343138a88c3e521dcb889
Source dataset
uspto-grants-2001_04
Patent number
US06218392B1

Reaction notes

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