Trifluoroacetic acid → HCID 22004376, compound

HRID 324348Notes

Reaction equation

HRID 324348 reaction equation
FC(F)(F)C(O)=O.C([O:12][C:13]([CH2:15][N:16]1[N:25]=[C:24]([NH:26][CH2:27][C:28]2[CH:33]=[CH:32][C:31]([O:34][CH3:35])=[C:30]([Cl:36])[CH:29]=2)[C:23]2[C:18](=[CH:19][CH:20]=[C:21]([C:37]#[N:38])[CH:22]=2)[C:17]1=[O:39])=[O:14])(C)(C)C>>[C:13]([CH2:15][N:16]1[N:25]=[C:24]([NH:26][CH2:27][C:28]2[CH:33]=[CH:32][C:31]([O:34][CH3:35])=[C:30]([Cl:36])[CH:29]=2)[C:23]2[C:18](=[CH:19][CH:20]=[C:21]([C:37]#[N:38])[CH:22]=2)[C:17]1=[O:39])([OH:14])=[O:12]

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 220043942-tert-Butoxycarbonylmethyl-4-(3-chloro-4-methoxybenzyl)amino-6-cyano-1(2H)-phthalazinone

Product 1

HCID 22004376HCID 22004376, compoundYield 16.7%

Procedure

Trifluoroacetic acid (5 ml) was added to 0.41 g of the t-butyl ester prepared in Example 22. The obtained mixture was stirred at room temperature for one hour and freed from the trifluoroacetic acid by vacuum distillation. The obtained residue was recrystallized from ethanol/water to give 0.06 g of the title compound as a yellow crystal.

Workup

  1. distillationfreed from the trifluoroacetic acid by vacuum distillation
  2. customThe obtained residue was recrystallized from ethanol/water

Sources & evidence

ORD record
ord-d4148c6106ae4272ab77359f5e4d6c28
Source dataset
uspto-grants-2001_04
Patent number
US06218392B1

Reaction notes

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