Benzo-1,3-dioxole-5-methylamine → HCID 21704216, compound

HRID 324355Notes

Reaction equation

HRID 324355 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([Cl:12])=[CH:9][CH:10]=2)[C:5]([NH:13][CH2:14][C:15]2[CH:20]=[CH:19][C:18]3[O:21][CH2:22][O:23][C:17]=3[CH:16]=2)=[N:4][N:3]=1.ClC1C2C(=CC=C(Cl)C=2)C(NCC2C=C[C:41]3[O:44]CO[C:40]=3C=2)=NN=1.Cl[C:48]1[C:57]2[C:52](=CC(Cl)=[CH:55][CH:56]=2)[C:51](Cl)=[N:50]N=1.C(N)C1C=CC2OC[O:64]C=2C=1>>[Cl:12][C:8]1[CH:7]=[C:6]2[C:11](=[CH:10][CH:9]=1)[C:2]([N:50]1[CH2:51][CH2:52][CH:57]([C:48]([O:44][CH2:41][CH3:40])=[O:64])[CH2:56][CH2:55]1)=[N:3][N:4]=[C:5]2[NH:13][CH2:14][C:15]1[CH:20]=[CH:19][C:18]2[O:21][CH2:22][O:23][C:17]=2[CH:16]=1

Participants

5

Reactant 4

HCID 75799Benzo-1,3-dioxole-5-methylamineHCID 10585735HCID 10585735, compoundHCID 22004384HCID 22004384, compoundHCID 22004403HCID 22004403, compound

Product 1

HCID 21704216HCID 21704216, compound

Procedure

A mixture (4.83 g) comprising 1,6-dichloro-4-(3,4-methylenedioxybenzyl)aminophthalazine and 4,6-dichloro-1-(3,4-methylenedioxybenzyl)aminophthalazine was prepared from 1,4,6-trichlorophthalazine (3.38 g) prepared in Preparative Example 7 and piperonylamine (2.21 g) in a similar manner to that of Example 1. The title compound (0.22 g) was prepared from 0.8 g of the mixture in a similar manner to that of Example 3 as a less polar product.

Sources & evidence

ORD record
ord-1e7ec6415b0a4197a90b9882854951c1
Source dataset
uspto-grants-2001_04
Patent number
US06218392B1

Reaction notes

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