Hydrochloric Acid → HCID 22004377, compound

HRID 324356Notes

Reaction equation

HRID 324356 reaction equation
C([O:3][C:4]([CH:6]1[CH2:11][CH2:10][N:9]([C:12]2[C:21]3[C:16](=[CH:17][C:18]([N+:22]([O-:24])=[O:23])=[CH:19][CH:20]=3)[C:15]([NH:25][CH2:26][C:27]3[CH:32]=[CH:31][C:30]([O:33][CH3:34])=[C:29]([Cl:35])[CH:28]=3)=[N:14][N:13]=2)[CH2:8][CH2:7]1)=[O:5])C.[ClH:36]>>[C:4]([CH:6]1[CH2:11][CH2:10][N:9]([C:12]2[C:21]3[C:16](=[CH:17][C:18]([N+:22]([O-:24])=[O:23])=[CH:19][CH:20]=3)[C:15]([NH:25][CH2:26][C:27]3[CH:32]=[CH:31][C:30]([O:33][CH3:34])=[C:29]([Cl:35])[CH:28]=3)=[N:14][N:13]=2)[CH2:8][CH2:7]1)([OH:5])=[O:3].[ClH:36].[C:4]([CH:6]1[CH2:11][CH2:10][N:9]([C:12]2[C:21]3[C:16](=[CH:17][C:18]([N+:22]([O-:24])=[O:23])=[CH:19][CH:20]=3)[C:15]([NH:25][CH2:26][C:27]3[CH:32]=[CH:31][C:30]([O:33][CH3:34])=[C:29]([Cl:35])[CH:28]=3)=[N:14][N:13]=2)[CH2:8][CH2:7]1)([OH:5])=[O:3]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 22004380HCID 22004380, compound

Product 2

HCID 22004377HCID 22004377, compoundHCID 22004378HCID 22004378, compound

Procedure

1-(4-Carboxypiperidino)-4-(3-chloro-4-methoxybenzyl)amino-6-nitrophthalazine was prepared from the compound prepared in Example 55 in a similar manner to that of Example 43 and further converted into the title compound in the same manner as that employed in Example 4 for the formation of hydrochloride.

Sources & evidence

ORD record
ord-03bc9e5d0c094cebbb03eeb168c062fe
Source dataset
uspto-grants-2001_04
Patent number
US06218392B1

Reaction notes

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