Acetone → HCID 69307921, compound

HRID 32436Notes

Reaction equation

HRID 32436 reaction equation
[Cl:1][C:2]1[C:10]2[C:5](=[CH:6][C:7]([C:11]([NH:13][CH:14]([C:24]3[CH:29]=[CH:28][C:27]([F:30])=[CH:26][CH:25]=3)[CH2:15][O:16][CH2:17][CH:18]3[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]3)=[O:12])=[CH:8][CH:9]=2)[NH:4][CH:3]=1.[CH3:31][C:32]([CH3:34])=O>C(#N)C>[Cl:1][C:2]1[C:10]2[C:5](=[CH:6][C:7]([C:11]([NH:13][CH:14]([C:24]3[CH:29]=[CH:28][C:27]([F:30])=[CH:26][CH:25]=3)[CH2:15][O:16][CH2:17][CH:18]3[CH2:23][CH2:22][N:21]([CH:32]([CH3:34])[CH3:31])[CH2:20][CH2:19]3)=[O:12])=[CH:8][CH:9]=2)[NH:4][CH:3]=1

Participants

4

Reactant 2

HCID 180AcetoneHCID 69309629HCID 69309629, compound

Product 1

HCID 69307921HCID 69307921, compoundYield 76%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Using alkylation method A, 3-chloro-N-[1-(4-fluoro-phenyl)-2-(piperidin-4-ylmethoxy)ethyl]-1H-indole-6-carboxamide (600 mg, 1.4 mmol) and acetone (10 mL, 135 mmol) afforded, after trituration (acetonitrile), 500 mg (76%) of the title compound.

Workup

  1. customafforded

Sources & evidence

ORD record
ord-d924d161d22940deac503ffab5e90c9d
Source dataset
uspto-grants-2008_09
Patent number
US07427632B2

Reaction notes

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