反应详情

A mixture of the product from step (i) (53.2 g) and lithium hydroxide monohydrate (52 g) in methanol (250 ml) and water (100 ml) was stirred at room temperature for 24 hours and partitioned between ethyl acetate and 2M HCl. The organic phase was washed with brine, dried (MgSO4), and evaporated under reduced pressure to afford an orange oil.

1. custompartitioned between ethyl acetate and 2M HCl
2. washThe organic phase was washed with brine
3. dry with materialdried (MgSO4)
4. customevaporated under reduced pressure
5. customto afford an orange oil