Methyl 3-(bromomethyl)benzoate → (+/-)-3-[[5-(7-Ethyl-9,10-dihydro-2-methyl-4H-benzo[5,6]cyclohepta[1,2-d]oxazol-4-yl)-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl]methyl]benzoic acid, methyl ester

HRID 324416Notes

Reaction equation

HRID 324416 reaction equation
[CH2:1]([C:3]1[CH:4]=[CH:5][C:6]2[CH:16]([C:17]3[C:18](=[O:24])[NH:19][C:20](=[O:23])[NH:21][CH:22]=3)[C:11]3[N:12]=[C:13]([CH3:15])[O:14][C:10]=3[CH2:9][CH2:8][C:7]=2[CH:25]=1)[CH3:2].Br[CH2:27][C:28]1[CH:29]=[C:30]([CH:35]=[CH:36][CH:37]=1)[C:31]([O:33][CH3:34])=[O:32]>>[CH2:1]([C:3]1[CH:4]=[CH:5][C:6]2[CH:16]([C:17]3[C:18](=[O:24])[NH:19][C:20](=[O:23])[N:21]([CH2:27][C:28]4[CH:29]=[C:30]([CH:35]=[CH:36][CH:37]=4)[C:31]([O:33][CH3:34])=[O:32])[CH:22]=3)[C:11]3[N:12]=[C:13]([CH3:15])[O:14][C:10]=3[CH2:9][CH2:8][C:7]=2[CH:25]=1)[CH3:2]

Participants

3

Reactant 2

HCID 517981Methyl 3-(bromomethyl)benzoateHCID 70114236(+/-)-5-(7-Ethyl-9,10-dihydro-2-methyl-4H-benzo[5,6]cyclohepta[1,2-d]oxazol-4-yl)-2,4(1H,3H)-pyrimidinedione

Product 1

HCID 131722510(+/-)-3-[[5-(7-Ethyl-9,10-dihydro-2-methyl-4H-benzo[5,6]cyclohepta[1,2-d]oxazol-4-yl)-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl]methyl]benzoic acid, methyl ester

Procedure

The subtitle compound was prepared from the product of step (ii) (0.38 g) and methyl 3-[bromomethyl]benzoate according to the method of example 1 step (viii).

Sources & evidence

ORD record
ord-d6c09d8b6e864a568deaf3bf7f670c5e
Source dataset
uspto-grants-2001_04
Patent number
US06218376B1

Reaction notes

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