HCID 131722512, compound → HCID 131722511, compound

HRID 324419Notes

Reaction equation

HRID 324419 reaction equation
[CH2:1]([C:3]1[CH:4]=[CH:5][C:6]2[C:16]([C:18]3[C:19](=[O:36])[NH:20][C:21](=[O:35])[N:22]([CH2:24][C:25]4[CH:26]=[C:27]([CH:32]=[CH:33][CH:34]=4)[C:28]([O:30][CH3:31])=[O:29])[CH:23]=3)(O)[C:11]3[N:12]=[C:13]([CH3:15])[S:14][C:10]=3[CH2:9][CH2:8][C:7]=2[CH:37]=1)[CH3:2]>C(O)(=O)C>[CH2:1]([C:3]1[CH:4]=[CH:5][C:6]2[CH:16]([C:18]3[C:19](=[O:36])[NH:20][C:21](=[O:35])[N:22]([CH2:24][C:25]4[CH:26]=[C:27]([CH:32]=[CH:33][CH:34]=4)[C:28]([O:30][CH3:31])=[O:29])[CH:23]=3)[C:11]3[N:12]=[C:13]([CH3:15])[S:14][C:10]=3[CH:9]=[CH:8][C:7]=2[CH:37]=1)[CH3:2]

Participants

3

Reactant 1

HCID 131722512HCID 131722512, compound

Product 1

HCID 131722511HCID 131722511, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A solution of the product from step (iv) (0.18 g) in glacial acetic acid (6 ml) was stirred at 100° C. for 2 hours. The solution was evaporated to dryness (azeotroped twice with toluene) and the residue purified by chromatography eluting with ethyl acetate.

Workup

  1. customThe solution was evaporated to dryness (
  2. customazeotroped twice with toluene) and the residue
  3. custompurified by chromatography
  4. washeluting with ethyl acetate

Sources & evidence

ORD record
ord-521c66cda8b844228ed37ed4baeec2e0
Source dataset
uspto-grants-2001_04
Patent number
US06218376B1

Reaction notes

Loading…