Ammonium Acetate → HCID 131722514, compound

HRID 324421Notes

Reaction equation

HRID 324421 reaction equation
[C:1]([O:4][CH:5]([C:11](=O)[CH2:12][CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[C:16]([CH3:20])[CH:15]=1)[C:6]([O:8][CH2:9][CH3:10])=[O:7])(=O)[CH3:2].C([O-])(=O)C.[NH4+:26]>C(O)(=O)C>[CH3:2][C:1]1[O:4][C:5]([C:6]([O:8][CH2:9][CH3:10])=[O:7])=[C:11]([CH2:12][CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([CH3:20])[CH:15]=2)[N:26]=1

Participants

4

Reactant 2

HCID 517165Ammonium AcetateHCID 131722513HCID 131722513, compound

Product 1

HCID 131722514HCID 131722514, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A mixture of the product from step (ii) (19.6 g) and ammonium acetate (25.8 g) in acetic acid (150 ml) was heated under reflux for 2 hours. The reaction mixture was evaporated to dryness and the residue partitioned between water and ethyl acetate. The organic phase was washed with aqueous sodium bicarbonate and water, dried (MgSO4) and evaporated under reduced pressure. The product was used without purification in the next step.

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 2 hours
  3. customThe reaction mixture was evaporated to dryness
  4. customthe residue partitioned between water and ethyl acetate
  5. washThe organic phase was washed with aqueous sodium bicarbonate and water
  6. dry with materialdried (MgSO4)
  7. customevaporated under reduced pressure
  8. customThe product was used without purification in the next step

Sources & evidence

ORD record
ord-525dc423af2143ae8262cfb46031ac02
Source dataset
uspto-grants-2001_04
Patent number
US06218376B1

Reaction notes

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