Methyl iodide → (+/-)-1-Methyl-5-(9,10-dihydro-4-hydroxy-2,7-dimethyl-4H-benzo[5,6]cyclohepta[1,2-d]oxazol-4-yl)-2,4(1H,3H)-pyrimidinedione

反応式

[OH:1][C:2]1([C:18]2[C:19](=[O:25])[NH:20][C:21](=[O:24])[NH:22][CH:23]=2)[C:8]2[N:9]=[C:10]([CH3:12])[O:11][C:7]=2[CH2:6][CH2:5][C:4]2[CH:13]=[C:14]([CH3:17])[CH:15]=[CH:16][C:3]1=2.[CH3:26]I>>[CH3:26][N:22]1[CH:23]=[C:18]([C:2]2([OH:1])[C:8]3[N:9]=[C:10]([CH3:12])[O:11][C:7]=3[CH2:6][CH2:5][C:4]3[CH:13]=[C:14]([CH3:17])[CH:15]=[CH:16][C:3]2=3)[C:19](=[O:25])[NH:20][C:21]1=[O:24]

参加物

反応物 2

HCID 6328Methyl iodide

HCID 70113848(+/-)-5-(9,10-Dihydro-4-hydroxy-2,7-dimethyl-4H-benzo[5,6]cyclohepta[1,2-d]oxazol-4-yl)-2,4(1H,3H)-pyrimidinedione

生成物 1

HCID 70112383(+/-)-1-Methyl-5-(9,10-dihydro-4-hydroxy-2,7-dimethyl-4H-benzo[5,6]cyclohepta[1,2-d]oxazol-4-yl)-2,4(1H,3H)-pyrimidinedione

実験手順

The subtitle compound was prepared from the product of example 14 step (vi) (1.55 g) and methyl iodide (0.284 ml) according to the method of example 15 step (i). Purification was by flash column chromatography eluting with 5% methanol in ethyl acetate.

後処理

customPurification
washeluting with 5% methanol in ethyl acetate

出典と根拠

ORDレコード: ord-d76e572386074e68b452e7d3630830f2
出典データセット: uspto-grants-2001_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06218376B1

反応ノート

読み込み中…