Uracil → HCID 22003606, compound

HRID 324436Notes

Reaction equation

HRID 324436 reaction equation
[NH:1]1[CH:8]=[CH:7][C:5](=[O:6])[NH:4][C:2]1=[O:3].[CH3:9][C:10]1[CH:25]=[CH:24][C:13]2[CH:14](O)[C:15]3[C:16]([CH:21]=[CH:22][C:12]=2[CH:11]=1)=[N:17][CH:18]=[CH:19][CH:20]=3>C(O)(=O)C>[CH3:9][C:10]1[CH:25]=[CH:24][C:13]2[CH:14]([C:7]3[C:5](=[O:6])[NH:4][C:2](=[O:3])[NH:1][CH:8]=3)[C:15]3[C:16]([CH:21]=[CH:22][C:12]=2[CH:11]=1)=[N:17][CH:18]=[CH:19][CH:20]=3

Participants

4

Reactant 2

HCID 1174UracilHCID 22003663HCID 22003663, compound

Product 1

HCID 22003606HCID 22003606, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A solution of uracil (1.87 g) and the product of step (iii) (3.73 g) in glacial acetic acid (30 ml) was heated at 120° C. under nitrogen for 40 hr. The solvent was evaporated under reduced pressure and the residue was partitioned between ethyl acetate and saturated. sodium bicarbonate solution. The organic phase was separated, dried (MgSO4) and evaporated under reduced pressure. Purification was by chromatography eluting with 0-20% methanol in ethyl acetate.

Workup

  1. customThe solvent was evaporated under reduced pressure
  2. customthe residue was partitioned between ethyl acetate
  3. customThe organic phase was separated
  4. dry with materialdried (MgSO4)
  5. customevaporated under reduced pressure
  6. customPurification
  7. washeluting with 0-20% methanol in ethyl acetate

Sources & evidence

ORD record
ord-99a1d7a9aab6460791e69b7db09d0643
Source dataset
uspto-grants-2001_04
Patent number
US06218376B1

Reaction notes

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