HCID 70112550, compound → HCID 70112974, compound

HRID 324440Notes

Reaction equation

HRID 324440 reaction equation
O[C:2]1([C:18]2[C:19](=[O:26])[NH:20][C:21](=[O:25])[N:22]([CH3:24])[CH:23]=2)[C:8]2[N:9]=[C:10]([CH3:12])[S:11][C:7]=2[CH2:6][CH2:5][C:4]2[CH:13]=[C:14]([CH3:17])[CH:15]=[CH:16][C:3]1=2>C(O)(=O)C>[CH3:24][N:22]1[CH:23]=[C:18]([CH:2]2[C:8]3[N:9]=[C:10]([CH3:12])[S:11][C:7]=3[CH:6]=[CH:5][C:4]3[CH:13]=[C:14]([CH3:17])[CH:15]=[CH:16][C:3]2=3)[C:19](=[O:26])[NH:20][C:21]1=[O:25]

Participants

3

Reactant 1

HCID 70112550HCID 70112550, compound

Product 1

HCID 70112974HCID 70112974, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A solution of the product from example 18 step (iii) (0.111 g) in glacial acetic acid (5 ml) was stirred at 100° C. for 3 h and evaporated. Purification of the residue was by flash chromatography, eluting with 40% acetone in isohexane to give the title compound.

Workup

  1. customevaporated
  2. customPurification of the residue
  3. washeluting with 40% acetone in isohexane

Sources & evidence

ORD record
ord-489e9bc1b9034158b131d1d428b7361c
Source dataset
uspto-grants-2001_04
Patent number
US06218376B1

Reaction notes

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